-Treat every gun as if it were loaded.
Accidents happen all the time. Be sure to not get careless. Know the status your weapon is in. Check, double check, triple check there is no round in the chamber before dry fire practice or cleaning your weapon.
-Keep your finger off of the trigger until you are o target and have made the decision to fire.
Most negligent discharges happen from people with poor trigger discipline.
-Never let your muzzle cross over anything that you are not willing to destroy.
Do not get careless. If you are not willing to pay for it, don`t chance it.
-Always be sure of your target and what is beyond it.
Make sure your target is actually a target you want to shoot. In a self-defense situation, this means target identification, making sure your target is actually a threat that warrants deadly force.
The second part of this is making sure there is a sufficient backstop behind your target. You do not want to shoot through your target and harm an innocent person